A woman with multiple sclerosis has a disabling relapse causing severe paraparesis. Infection has been excluded. Oral methylprednisolone 0.5 g daily

Question

A woman with multiple sclerosis has a disabling relapse causing severe paraparesis. Infection has been excluded. Oral methylprednisolone 0.5 g daily for 5 days was not tolerated because of vomiting; admission is required to monitor brittle diabetes. Which regimen is now most appropriate?

Accepted Answer

Intravenous methylprednisolone 1 g daily for 3 to 5 days in hospital

Answer

Oral prednisolone 60 mg daily for 10 days followed by a taper

Answer

Plasma exchange immediately without a further corticosteroid strategy

Answer

Oral methylprednisolone 100 mg daily for 7 days with antiemetic cover

Answer

Intravenous dexamethasone 8 mg daily for 5 days without monitoring

Cerebral Venous Sinus Thrombosis – Post-Partum — SCE Neurology MCQ

A woman with multiple sclerosis has a disabling relapse causing severe paraparesis. Infection has been excluded. Oral methylprednisolone 0.5 g daily for 5 days was not tolerated because of vomiting; admission is required to monitor brittle diabetes. Which regimen is now most appropriate?