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Guillain-Barré Syndrome – AIDP — SCE Neurology MCQ

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EasyPeripheral Neuropathy & NeuromuscularGuillain-Barré Syndrome – AIDPSCE Neurology

A 55-year-old man presents with progressive ascending weakness over 10 days, areflexia, and distal paraesthesiae. He had a Campylobacter jejuni gastroenteritis 2 weeks ago. Nerve conduction studies show reduced motor conduction velocities, prolonged distal latencies, and conduction block in multiple nerves. CSF shows protein 1.2 g/L with 2 cells/µL. What is the diagnosis?

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Correct answer: D — Acute inflammatory demyelinating polyneuropathy (AIDP)

This is classic AIDP (the most common variant of Guillain-Barré syndrome): ascending weakness, areflexia, post-infectious onset, demyelinating NCS pattern (slowed CV, prolonged DML, conduction block), and albuminocytological dissociation in CSF. B: AMAN is axonal variant (reduced CMAP amplitudes without demyelinating features). C: CIDP requires symptoms >8 weeks. D: MMN is a chronic, purely motor neuropathy with conduction block. E: Transverse myelitis would show upper motor neurone signs and a sensory level.

Reference: ABN GBS Guidelines; EAN/PNS GBS Guidelines (2023)