skip to main content

Acute Disseminated Encephalomyelitis — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardMultiple Sclerosis & CNS InflammationAcute Disseminated EncephalomyelitisSCE Neurology

A 31-year-old with serum MOG-IgG has severe bilateral optic neuritis. After intravenous methylprednisolone 1 g daily for 5 days, visual acuity remains counting fingers. Which escalation is most consistent with specialist practice for a severe incompletely recovered adult MOGAD attack?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Urgent plasma exchange or immunoadsorption

Explanation lettering: C = shown as A · D = shown as C · E = shown as D · A = shown as E

A is an MS disease-modifying treatment, not acute rescue for MOGAD. B risks irreversible visual loss. C has delayed onset and is not sole acute rescue. D is correct: severe adult MOGAD attacks with incomplete response to 3–5 days of high-dose corticosteroid are commonly escalated promptly to plasma exchange or immunoadsorption. E is neither an adequate anti-inflammatory dose nor a safe disposition.

Reference: Treatment of MOG-antibody-associated disorders: international survey: https://pmc.ncbi.nlm.nih.gov/articles/PMC7954658/