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Wake-Up Stroke — SCE Neurology MCQ

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HardCerebrovascular DiseaseWake-Up StrokeSCE Neurology

An adult with drug-resistant focal-onset seizures needs an add-on medicine. Genetic cardiology has confirmed familial short-QT syndrome. Which antiseizure medicine is specifically contraindicated by its current UK product information?

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Correct answer: E — Cenobamate

Cenobamate shortens the QT interval and the UK SmPC lists familial short-QT syndrome as a contraindication. Brivaracetam, perampanel, zonisamide and pregabalin each require their usual interaction, psychiatric, renal or pregnancy assessments, but familial short-QT syndrome is not their specific labelled contraindication. Cenobamate also requires slow titration because rapid escalation has been associated with DRESS.

Reference: ONTOZRY 25 mg tablets UK summary of product characteristics (Current UK SmPC, accessed July 2026): https://www.medicines.org.uk/emc/product/14635/smpc