skip to main content

ADPKD ICA Prevalence 6-12 Percent — ESENeph MCQ

Instant feedback + full explanation. One question, done properly.

ModeratePolycystic Kidney DiseaseADPKD ICA Prevalence 6-12 PercentESENeph

A 50-year-old man with ADPKD and eGFR 40 mL/min/1.73m2 presents with sudden-onset severe headache, neck stiffness, and photophobia. He has not been screened for intracranial aneurysms. CT head shows subarachnoid haemorrhage. His family history is negative for intracranial events. What is the approximate prevalence of intracranial aneurysms in ADPKD compared to the general population?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Approximately 6-12% (2-4 times general population)

The prevalence of intracranial aneurysms in ADPKD is approximately 6-12%, compared to 2-3% in the general population — a 2-4 fold increase. The risk is higher in patients with a positive family history of intracranial aneurysm (~20%). Screening with MRA is recommended for patients with family history of intracranial aneurysm/SAH. Screening in patients without family history is debated — KDIGO and most expert groups recommend it before high-risk activities, before major surgery, or in patients with anxiety. This patient's negative family history does not eliminate risk. Polycystin deficiency in vascular smooth muscle contributes to arterial wall weakness.

Reference: Vlak et al 2011 – ICA Prevalence ADPKD; KDIGO 2015 – ADPKD Controversies