DAPA-CKD Trial Population Inclusion — ESENeph MCQ
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Correct answer: A — DAPA-CKD enrolled adults with eGFR 25-75 mL/min/1.73m2 and uACR 200-5000 mg/g (~22-565 mg/mmol) with or without type 2 diabetes
DAPA-CKD (2020, NEJM) was a landmark kidney outcomes trial of Dapagliflozin. Key inclusion: eGFR 25-75, uACR 200-5000 mg/g, stable RASi dose. Crucially, 32% of participants were non-diabetic – making it the first major trial to show SGLT2i kidney benefit regardless of diabetes. The 39% risk reduction in the primary composite was consistent across diabetic and non-diabetic subgroups. The trial was stopped early for overwhelming efficacy. Together with CREDENCE (Canagliflozin, diabetic only) and EMPA-KIDNEY (broader population), it established SGLT2i as fundamental CKD therapy.
Reference: https://guidelines.ukkidney.org