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SPK Survival Benefit vs Dialysis — ESENeph MCQ

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HardTransplantationSPK Survival Benefit vs DialysisESENeph

An EBV-seropositive adult receives a de-novo kidney transplant and starts belatacept. Which sequence matches the initial and maintenance NULOJIX schedule?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — 10 mg/kg on all six loading visits; then 6 mg/kg four-weekly from week 16

Explanation lettering: E = shown as B · B = shown as C · C = shown as E

B is correct. De-novo belatacept uses 10 mg/kg before implantation on day 1, then days 5, 14 and 28 and the ends of weeks 8 and 12. Maintenance is 6 mg/kg every four weeks, with a three-day window, starting at the end of week 16. Conversion regimens used months after transplantation are different and should not be substituted.

Reference: NULOJIX 250 mg powder for concentrate for solution for infusion SmPC: https://www.medicines.org.uk/emc/product/4685/smpc