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MPAA Leucopenia Dose Adjustment LN — ESENeph MCQ

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ModerateGlomerulonephritisMPAA Leucopenia Dose Adjustment LNESENeph

A 30-year-old woman with SLE and Class IV LN on MPAA develops leucopenia (WCC 2.5). Anti-dsDNA is falling and C3 improving. How should MPAA be managed?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Reduce mycophenolate and monitor the blood count

MPAA leucopenia is dose-dependent. Differentiating drug-induced from SLE-related requires clinical judgement – improving serological markers here suggest drug cause. The clinical features in the stem make this the single best answer among the listed alternatives.

Reference: https://guidelines.ukkidney.org