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Lp(a) Elevation Nephrotic — ESENeph MCQ

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ModerateGlomerulonephritisLp(a) Elevation NephroticESENeph

A 40-year-old man with nephrotic FSGS has Lp(a) of 250 nmol/L and cholesterol 12 mmol/L. Is elevated Lp(a) related to nephrotic syndrome?

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Correct answer: C — Yes – hepatic Lp(a) synthesis is upregulated in nephrotic syndrome; Lp(a) is an independent CV risk factor that normalises with remission

Lp(a) elevation in nephrotic syndrome is from increased hepatic synthesis driven by hypoalbuminaemia. It typically normalises with remission. No specific Lp(a)-lowering therapy is routinely available.

Reference: KDIGO 2021 – GN; Kronenberg 2016