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DRA Only Transplant Halts Progression — ESENeph MCQ

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HardHaemodialysisDRA Only Transplant Halts ProgressionESENeph

A patient taking Jinarc for ADPKD progresses from late CKD stage 4 to CKD stage 5 despite good adherence and acceptable liver tests. What does the product information require?

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Correct answer: B — Discontinue Jinarc on progression to CKD stage 5

Explanation lettering: B = shown as A · E = shown as B · D = shown as C · A = shown as D · C = shown as E

E is correct. Jinarc is authorised for ADPKD with CKD stages 1–4 at initiation, and the SmPC instructs discontinuation if renal insufficiency progresses to CKD stage 5 because safety and efficacy there have not been explored. The CYP3A4 dose-reduction schedules do not provide a CKD-stage-5 regimen.

Reference: Jinarc 90 mg + 30 mg tablets SmPC: https://www.medicines.org.uk/emc/product/6854/smpc