IgAN Proteinuria Target 0.5 KDIGO 2025 — ESENeph MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: C — The proteinuria target is <0.5 g/day ideally <0.3 g/day on or off treatment – this is stricter than previous guidelines
KDIGO 2025 IgAN guideline lowered the proteinuria target from the historical <1 g/day to <0.5 g/day, ideally <0.3 g/day, based on evidence that higher residual proteinuria is associated with continued nephron loss. This target applies 'on or off treatment' – meaning it should be maintained after disease-modifying therapy courses end. At 0.6 g/day, this patient is improving but has not yet reached target. Optimising supportive care (ensure maximum RASi dose, SGLT2i continued, BP <120 systolic) may achieve the final reduction, or the Nefecon course (9 months total) may provide further benefit.
Reference: KDIGO 2025 – IgA Nephropathy Guideline