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Erectile Dysfunction CKD Multifactorial — ESENeph MCQ

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HardChronic Kidney DiseaseErectile Dysfunction CKD MultifactorialESENeph

A patient tolerates Jinarc 90 mg on waking plus 30 mg 8 hours later for ADPKD. Diltiazem, a moderate CYP3A4 inhibitor, is now required. Which reduced Jinarc regimen is specified?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Reduce from 90+30 mg to 45+15 mg

Explanation lettering: B = shown as A · A = shown as B · E = shown as C · C = shown as D · D = shown as E

C is correct. With a moderate CYP3A4 inhibitor, the 90+30 mg Jinarc regimen is reduced to 45+15 mg. By contrast, strong CYP3A4 inhibition converts the higher split regimens to 30 mg once daily. Dose separation does not prevent enzyme-mediated exposure changes, and 30+15 mg is the moderate-inhibitor reduction for the 60+30 mg regimen.

Reference: Jinarc 90 mg + 30 mg tablets SmPC: https://www.medicines.org.uk/emc/product/6854/smpc