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Thiazide Calcium Reabsorption Mechanism — ESENeph MCQ

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HardTubular DisordersThiazide Calcium Reabsorption MechanismESENeph

A woman of childbearing potential is selected for sparsentan for primary IgA nephropathy. Which condition must be met before the first dose?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Verify absence of pregnancy and ensure effective contraception is being used

Explanation lettering: D = shown as B · B = shown as C · E = shown as D · C = shown as E

A is correct. Pregnancy is a contraindication. Sparsentan may be initiated in a woman of childbearing potential only after absence of pregnancy has been verified and effective contraception is practised. The precautions apply from initiation rather than only after titration, and proteinuria severity does not waive the fetal-risk restriction.

Reference: Filspari 200 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/100610/smpc