skip to main content

Haemoperitoneum PD Non-Infective — ESENeph MCQ

Instant feedback + full explanation. One question, done properly.

HardPeritoneal DialysisHaemoperitoneum PD Non-InfectiveESENeph

An otherwise eligible patient with IgA nephropathy has persistent baseline ALT 2.4 times the upper limit of normal and normal bilirubin. What should be done about sparsentan initiation?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Defer initiation while aminotransferases remain above 2 times normal

Explanation lettering: D = shown as A · A = shown as D

E is correct. Clinical experience is limited when AST or ALT exceeds twice the upper limit of normal, and the SmPC states that sparsentan should not be initiated above that threshold. Normal bilirubin does not override the entry criterion. For treated patients, aminotransferases and bilirubin are checked before treatment and every three months.

Reference: Filspari 200 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/100610/smpc