Fluid Overload Missed Dialysis Emergency — ESENeph MCQ
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Correct answer: E — Stop candesartan because co-administration of sparsentan with an ARB is contraindicated
Explanation lettering: B = shown as A · C = shown as B · A = shown as C · E = shown as D · D = shown as E
D is correct. Sparsentan already antagonises the angiotensin-II type-1 receptor, and co-administration with another ARB such as candesartan is contraindicated. Endothelin-receptor antagonists and renin inhibitors are also contraindicated combinations. Timing separation or potassium selection does not remove pharmacodynamic dual blockade.
Reference: Filspari 200 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/100610/smpc