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Nefecon 9 Month Duration NefIgArd — ESENeph MCQ

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ModerateGlomerulonephritisNefecon 9 Month Duration NefIgArdESENeph

A 42-year-old woman with IgA nephropathy and CKD G3b has been on Nefecon for 9 months. According to the NefIgArd trial protocol, what happens after 9 months of Nefecon treatment?

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Correct answer: B — Nefecon is stopped at 9 months; the NefIgArd trial showed sustained eGFR benefit at 2 years (15 months after treatment cessation)

In the NefIgArd Phase 3 trial, Nefecon was given for 9 months and then stopped. At the 2-year follow-up (15 months after cessation), the eGFR benefit was sustained compared to placebo. This suggests that the 9-month course provides durable disease modification by reducing pathogenic IgA production at the mucosal immune level (Peyer's patches). Whether repeated courses are needed for patients who relapse is being studied. KDIGO 2025 reflects this 9-month treatment paradigm.

Reference: NefIgArd Trial – Lancet 2023; KDIGO 2025 – IgAN Guideline