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DCD vs DBD Transplant Outcomes — ESENeph MCQ

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HardTransplantationDCD vs DBD Transplant OutcomesESENeph

Sparsentan is initiated for an eligible adult with primary IgA nephropathy. Blood pressure, potassium and liver tests permit treatment. Which titration is specified?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Give 200 mg daily for 14 days, then 400 mg if tolerated

Explanation lettering: D = shown as A · C = shown as B · A = shown as C · E = shown as D · B = shown as E

C is correct. Filspari starts at 200 mg once daily for 14 days and then increases to the 400 mg once-daily maintenance dose according to tolerability. Hypotension, oedema or hyperkalaemia can require adjustment of concomitant medicines, temporary down-titration or interruption. There is no twice-daily or 600 mg regimen.

Reference: Filspari 200 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/100610/smpc