HCQ Mandatory SLE — ESENeph MCQ

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EasyGlomerulonephritisHCQ Mandatory SLEESENeph

A 30-year-old woman with SLE develops Class IV lupus nephritis. According to KDIGO 2024, which background medication must all SLE patients (including those with LN) receive unless contraindicated?

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Correct answer: C — Hydroxychloroquine

KDIGO 2024 LN guideline recommends (1C) that all patients with SLE, including those with lupus nephritis, should be treated with Hydroxychloroquine or an equivalent antimalarial unless contraindicated. HCQ reduces LN flare rates, improves survival, has antithrombotic properties, and provides cardiovascular benefit. It should be continued throughout pregnancy. The main contraindication is pre-existing retinal disease. Ophthalmological screening is recommended after 5 years of use.

Reference: KDIGO 2024 – Lupus Nephritis Guideline (Recommendation 10.2.1.1)