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IgAN Prediction Tool Variables — ESENeph MCQ

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ModerateGlomerulonephritisIgAN Prediction Tool VariablesESENeph

A 45-year-old man with IgA nephropathy and eGFR 50 mL/min/1.73m2 asks about the long-term prognosis. He has proteinuria of 0.8 g/day on maximal supportive care. The International IgAN Prediction Tool at biopsy estimated a 10% 5-year risk of kidney failure. What factors are included in this prediction tool?

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Correct answer: D — eGFR, proteinuria, blood pressure, age, MEST-C biopsy scores, and race/ethnicity are included in various versions of the tool

The International IgAN Prediction Tool incorporates multiple clinical and histological variables at the time of biopsy (and at 1-2 years post-biopsy for the post-biopsy version). Variables include: eGFR, proteinuria, blood pressure, age, MEST-C histological scores (mesangial hypercellularity, endocapillary proliferation, segmental sclerosis, tubular atrophy/interstitial fibrosis, crescents), and race/ethnicity. KDIGO 2025 IgAN guideline recommends using these validated tools for risk stratification, though they should not alone guide specific therapy decisions.

Reference: KDIGO 2025 – IgAN Guideline; Barbour et al 2019 – IgAN Prediction Tool