A 50-year-old man with nephrotic syndrome from MCD has massive oedema. He is on Furosemide 120 mg BD but response is poor. His albumin is 10 g/L.

Question

A 50-year-old man with nephrotic syndrome from MCD has massive oedema. He is on Furosemide 120 mg BD but response is poor. His albumin is 10 g/L. What is contributing to diuretic resistance in nephrotic syndrome?

Accepted Answer

Hypoalbuminaemia causes reduced delivery of protein-bound Furosemide to its site of action in the Loop of Henle

Answer

Tubular secretion of Furosemide is increased as the preferred next management strategy in this patient

Answer

Diuretic resistance does not occur in nephrotic syndrome as the preferred next management strategy

Answer

Furosemide is inactivated in nephrotic syndrome as the preferred next management strategy in this patient

Answer

Nephrotic syndrome causes Furosemide allergy as the preferred next management strategy in this patient

Diuretic Resistance Nephrotic Syndrome — ESENeph MCQ

A 50-year-old man with nephrotic syndrome from MCD has massive oedema. He is on Furosemide 120 mg BD but response is poor. His albumin is 10 g/L. What is contributing to diuretic resistance in nephrotic syndrome?