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Calcium Phosphate Stones Distal RTA — ESENeph MCQ

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ModerateRenal Stone DiseaseCalcium Phosphate Stones Distal RTAESENeph

A 40-year-old woman with recurrent calcium phosphate stones has a consistently alkaline urine (pH 7.2-7.5) and a mild non-anion gap metabolic acidosis (bicarbonate 19 mmol/L). Serum potassium is 3.0 mmol/L. What is the most likely underlying diagnosis?

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Correct answer: AIncomplete distal (type 1) renal tubular acidosis

Recurrent calcium phosphate stones (which form preferentially in alkaline urine) combined with persistently alkaline urine pH (>6.5), mild metabolic acidosis, and hypokalaemia is the classic presentation of incomplete (or complete) distal RTA. The distal tubule fails to secrete hydrogen ions adequately, maintaining alkaline urine. This alkaline milieu promotes calcium phosphate (apatite/brushite) crystallisation. Treatment is potassium citrate, which corrects acidosis and provides citrate as a stone inhibitor.

Reference: EAU 2024 – Urolithiasis; Rodríguez-Soriano 2002 – RTA Review