Calcium Phosphate Stones Distal RTA — ESENeph MCQ
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Correct answer: A — Incomplete distal (type 1) renal tubular acidosis
Recurrent calcium phosphate stones (which form preferentially in alkaline urine) combined with persistently alkaline urine pH (>6.5), mild metabolic acidosis, and hypokalaemia is the classic presentation of incomplete (or complete) distal RTA. The distal tubule fails to secrete hydrogen ions adequately, maintaining alkaline urine. This alkaline milieu promotes calcium phosphate (apatite/brushite) crystallisation. Treatment is potassium citrate, which corrects acidosis and provides citrate as a stone inhibitor.
Reference: EAU 2024 – Urolithiasis; Rodríguez-Soriano 2002 – RTA Review