MN Highest Thrombotic Risk — ESENeph MCQ

Instant feedback + full explanation. One question, done properly.

EasyGlomerulonephritisMN Highest Thrombotic RiskESENeph

A 32-year-old woman presents with sudden-onset nephrotic syndrome. She has a serum albumin of 11 g/L. She is found to have bilateral renal vein thrombosis on CT venography. Which primary glomerular disease has the highest risk of thrombotic complications?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Membranous nephropathy

Membranous nephropathy has the highest risk of thrombotic complications among primary glomerular diseases. This is due to massive urinary losses of anticoagulant proteins (antithrombin III, protein C, protein S) with concurrent hepatic overproduction of procoagulant factors. Renal vein thrombosis, DVT, and PE are all well-recognised. KDIGO 2021 specifically highlights MN and recommends considering prophylactic anticoagulation when albumin <20 g/L.

Reference: KDIGO 2021 – Glomerular Disease Guideline