AV Fistula Maturation Rule of 6s — ESENeph MCQ
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Correct answer: D — Monoclonal gammopathy of renal significance
The best answer is “Monoclonal gammopathy of renal significance”. MGRS captures kidney-damaging monoclonal proteins from clones too small to meet ordinary haematological treatment thresholds; clone characterization then guides treatment. “Multiple myeloma by definition” is less appropriate because the clone does not meet malignancy criteria and kidney toxicity defines MGRS “Primary focal segmental glomerulosclerosis” is less appropriate because the monotypic immune deposits identify another mechanism “Polyclonal infection-related glomerulonephritis” is less appropriate because the deposits are monotypic and linked to a clone “Thin basement membrane nephropathy” is less appropriate because this does not cause monoclonal proliferative deposits
Reference: International Kidney and Monoclonal Gammopathy Research Group consensus: https://pmc.ncbi.nlm.nih.gov/articles/PMC7136169/