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Belimumab Maintenance LN — ESENeph MCQ

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ModerateGlomerulonephritisBelimumab Maintenance LNESENeph

A 62-year-old woman with lupus nephritis Class IV achieved complete remission on triple therapy (Belimumab + MPAA + Glucocorticoids). She is now on maintenance Belimumab, MPAA, and low-dose Prednisolone. According to KDIGO 2024, can Belimumab be continued during maintenance?

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Correct answer: A — Yes – patients treated with triple regimens including Belimumab can continue it as maintenance therapy

KDIGO 2024 LN guideline practice point 10.2.3.2.5 states that patients treated with triple immunosuppressive regimens that include Belimumab or a CNI in addition to standard therapy can continue with a triple immunosuppressive regimen as maintenance therapy. The BLISS-LN trial showed continued benefit of Belimumab through the maintenance phase.

Reference: KDIGO 2024 – Lupus Nephritis Guideline; BLISS-LN Trial – NEJM 2020