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FLOW Trial Semaglutide CKD — ESENeph MCQ

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ModerateDiabetic Kidney DiseaseFLOW Trial Semaglutide CKDESENeph

A 60-year-old man with CKD G4 and type 2 diabetes has been on Semaglutide for 6 months. His HbA1c has improved from 68 to 52 mmol/mol and he has lost 8 kg. His eGFR has remained stable. The recent FLOW trial is discussed. What did the FLOW trial demonstrate?

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Correct answer: CSemaglutide reduced the risk of kidney disease progression and cardiovascular death in patients with T2D and CKD

The FLOW trial (2024) was the first dedicated kidney outcomes trial of a GLP-1 RA. It demonstrated that Semaglutide 1 mg weekly significantly reduced the primary composite outcome (kidney disease progression, kidney death, cardiovascular death) by 24% in patients with T2D and CKD (eGFR 25-75, uACR 300-5000). The trial was stopped early for overwhelming efficacy. This supports KDIGO 2024's recommendation of GLP-1 RA as part of the comprehensive CKD management approach.

Reference: https://guidelines.ukkidney.org