Three days after co-trimoxazole is started, a CKD patient’s creatinine rises by 12% and potassium from 4.7 to 5.8 mmol/L. Urine output and

Question

Three days after co-trimoxazole is started, a CKD patient’s creatinine rises by 12% and potassium from 4.7 to 5.8 mmol/L. Urine output and haemodynamics are unchanged. Which combined pharmacological explanation is most accurate?

Accepted Answer

Trimethoprim reduces renal tubular creatinine secretion and distal sodium transport

Answer

Trimethoprim causes obligatory glomerular necrosis whenever creatinine and potassium rise together

Answer

Trimethoprim increases renal creatinine secretion while inducing proximal potassium wasting

Answer

Sulfamethoxazole blocks cystatin-C filtration while trimethoprim increases gastrointestinal potassium uptake

Answer

Sulfamethoxazole increases creatinine production and stimulates aldosterone, raising creatinine but lowering potassium

Sacubitril Creatinine Interference — ESENeph MCQ

Three days after co-trimoxazole is started, a CKD patient’s creatinine rises by 12% and potassium from 4.7 to 5.8 mmol/L. Urine output and haemodynamics are unchanged. Which combined pharmacological explanation is most accurate?