skip to main content

Anti-GBM Transplant Timing — ESENeph MCQ

Instant feedback + full explanation. One question, done properly.

EasyTransplantationAnti-GBM Transplant TimingESENeph

A 28-year-old woman with known anti-GBM disease and dialysis-dependent ESKD is being considered for transplantation. Her anti-GBM antibodies became undetectable 4 months ago. Is she ready for transplant listing?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — No – anti-GBM antibodies should be undetectable for at least 6 months before transplantation

Anti-GBM antibodies must be undetectable for at least 6 months (some centres recommend 12 months) before transplant listing. This minimises the risk of recurrence in the allograft. Recurrence risk is very low (<5%) when this criterion is met. She should continue to be monitored for anti-GBM antibody recurrence. If double-positive (ANCA + anti-GBM), the ANCA should also be considered when assessing transplant timing.

Reference: KDIGO 2021 – GN Guideline; KDIGO 2020 – Transplant Candidate Evaluation