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Snake Bite AKI TMA — ESENeph MCQ

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HardAcute Kidney InjurySnake Bite AKI TMAESENeph

A patient with CKD and heart failure develops increasing oedema while taking sodium zirconium cyclosilicate 10 g once daily. Which formulation fact is most relevant to the review?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Each 5 g dose contains about 400 mg sodium

Explanation lettering: E = shown as A · A = shown as B · B = shown as D · D = shown as E

D is correct. Every 5 g of sodium zirconium cyclosilicate contains approximately 400 mg sodium, equivalent to about 800 mg with a 10 g daily dose. In a salt-sensitive patient, that exposure is relevant to oedema and volume review. The content is intrinsic to dose rather than sachet presentation, and it should prompt clinical assessment rather than an automatic assumption that dialysis is required.

Reference: Lokelma 5 g powder for oral suspension SmPC: https://www.medicines.org.uk/emc/product/10059/smpc