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IgAN Proteinuria Target — ESENeph MCQ

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EasyGlomerulonephritisIgAN Proteinuria TargetESENeph

A 42-year-old woman with IgA nephropathy and proteinuria 0.8 g/day on maximal RASi and SGLT2i has eGFR 58 mL/min/1.73m2. According to KDIGO 2025 IgAN guideline, what is the proteinuria goal?

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Correct answer: C — <0.5 g/day ideally <0.3 g/day

KDIGO 2025 IgAN guideline lowered the proteinuria target to <0.5 g/day, ideally <0.3 g/day, on or off treatment. This stricter target reflects evidence that higher residual proteinuria is associated with progressive kidney function decline. The previous target of <1 g/day is now considered insufficient.

Reference: KDIGO 2025 – IgA Nephropathy and IgA Vasculitis Guideline