ESA Target Haemoglobin — ESENeph MCQ

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EasyChronic Kidney DiseaseESA Target HaemoglobinESENeph

A 60-year-old man with established CKD G5D on haemodialysis has a haemoglobin of 105 g/L on Darbepoetin. His target is 100-115 g/L. His Tacrolimus level is being checked for a transplant assessment. What haemoglobin range does KDIGO 2025 recommend avoiding?

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Correct answer: E — Above 130 g/L

KDIGO 2025 anemia guideline recommends that Hb should not be intentionally maintained above 130 g/L with ESA therapy in adults with CKD. The TREAT, CREATE, and CHOIR trials showed increased cardiovascular events and stroke when targeting Hb >130 g/L. The generally recommended range is 100-115 g/L for most CKD patients, though individualisation is appropriate. His current Hb of 105 g/L is within range.

Reference: KDIGO 2025 – Anemia in CKD Guideline