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SGLT2i Non-Diabetic CKD — ESENeph MCQ

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ModerateChronic Kidney DiseaseSGLT2i Non-Diabetic CKDESENeph

A 52-year-old man with CKD G4A3 (eGFR 25 mL/min/1.73m2) on Ramipril 10 mg has BP 138/86 mmHg. He does not have diabetes. His uACR is 65 mg/mmol. According to KDIGO 2024 CKD guideline, what is the recommended SGLT2i indication?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — SGLT2i is recommended (1A) as he has eGFR ≥20 and ACR ≥200 mg/g (≥20 mg/mmol)

KDIGO 2024 recommends SGLT2i (1A) for adults with CKD, eGFR ≥20 mL/min/1.73m2, and uACR ≥200 mg/g (≥20 mg/mmol), irrespective of diabetes status. This patient has uACR 65 mg/mmol (approximately 650 mg/g), well above threshold. EMPA-KIDNEY and DAPA-CKD demonstrated benefits regardless of diabetes.

Reference: KDIGO 2024 – Clinical Practice Guideline for CKD