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Conn Syndrome — ESENeph MCQ

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EasyElectrolyte DisordersConn SyndromeESENeph

A 27-year-old man presents with a serum potassium of 2.2 mmol/L, metabolic alkalosis, and hypertension. His renin is suppressed and aldosterone is elevated. 24-hour urinary potassium is 65 mmol/day (elevated). CT adrenals shows a 2 cm left adrenal adenoma. What is the diagnosis?

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Correct answer: A — Conn syndrome

Hypokalaemia with metabolic alkalosis, suppressed renin, elevated aldosterone, and an adrenal adenoma is classic for Conn syndrome (aldosterone-producing adenoma). Liddle syndrome has low renin and low aldosterone. Cushing syndrome may cause hypokalaemia but with other clinical features. Phaeochromocytoma causes episodic hypertension with catecholamine symptoms. Renal artery stenosis would cause high renin and high aldosterone (secondary hyperaldosteronism).

Reference: https://guidelines.ukkidney.org