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Hyperkalaemia — ESENeph MCQ

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ModerateElectrolyte DisordersHyperkalaemiaESENeph

A 55-year-old woman with CKD G4A3 (eGFR 22 mL/min/1.73m2) has a potassium of 6.2 mmol/L. Her ECG shows peaked T waves. She is on Ramipril 10 mg, Dapagliflozin 10 mg, and Spironolactone 25 mg. After initial emergency management, which medication should be stopped first?

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Correct answer: DSpironolactone

In the context of hyperkalaemia with ECG changes, the drug most likely to be contributing and the least evidence-based for renal protection in this scenario is Spironolactone (steroidal MRA). RASi and SGLT2i have strong evidence for slowing CKD progression and should be maintained if possible. KDIGO 2024 emphasises continuing ACEi/ARB even when eGFR falls below 30. SGLT2i has kidney-protective benefit. Spironolactone lacks the outcome data of finerenone in CKD and is the appropriate medication to discontinue first.

Reference: KDIGO 2024 – Clinical Practice Guideline for CKD; NICE CG182 2024 update