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Post-Zoster Shingrix Timing — SCE Infectious Diseases MCQ

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EasyTravel Medicine & VaccinationPost-Zoster Shingrix TimingSCE Infectious Diseases

A 35-year-old man with HIV on ART develops a first episode of shingles (VZV) in the T10 dermatome. He is well-controlled (CD4 520, VL <50). He has not been vaccinated against shingles. After recovery, when should Shingrix be administered?

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Correct answer: B — After the acute episode has resolved (all lesions crusted, typically 2–4 weeks) — Shingrix can then be given as a 2-dose series (0 and 2–6 months) to prevent future episodes

Shingrix (recombinant, adjuvanted zoster vaccine) should be offered to PLWH after recovery from a zoster episode to prevent future recurrences. Timing: after the acute episode has resolved (all lesions crusted, clinical recovery — typically 2–4 weeks). The two-dose series (0 and 2–6 months apart) provides >90% protection. Shingrix is the ONLY zoster vaccine recommended for immunocompromised patients (Zostavax — live — is contraindicated). JCVI extended Shingrix eligibility to immunocompromised patients aged 50+ in 2023.

Reference: UKHSA 2024 – Green Book Ch 28a; BHIVA 2024 – Vaccination; JCVI 2023