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ART Vomiting Redose Rule — SCE Infectious Diseases MCQ

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EasyHIV MedicineART Vomiting Redose RuleSCE Infectious Diseases

A 30-year-old man with HIV on DTG/TAF/FTC develops acute gastroenteritis with vomiting. He vomits 30 minutes after taking his morning ART dose. Should he take a repeat dose?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — If vomiting occurs within 1 hour of the dose, a repeat dose should be taken; if >1 hour, the drug is likely absorbed and no repeat is needed — for DTG (once daily), redose if vomiting within 1 hour

He should take a repeat dose now. Vomiting 30 minutes after the morning DTG/TAF/FTC dose is within the usual 1-hour redosing window used for oral antiretrovirals in this regimen, so absorption may be incomplete. If vomiting occurs more than 1 hour after the dose, the dose is generally regarded as absorbed and the next dose should be taken at the usual scheduled time. He should not double the next day, stop ART, or redose regardless of timing.

Reference: electronic Medicines Compendium (eMC). Emtricitabine/Tenofovir Alafenamide Gilead 200 mg/25 mg film-coated tablets Summary of Product Characteristics, section 4.2, 2025. https://www.medicines.org.uk/emc/product/2108/smpc