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Hookworm Egg Morphology — SCE Infectious Diseases MCQ

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ModerateParasitologyHookworm Egg MorphologySCE Infectious Diseases

A 60-year-old man with a history of recent travel to the tropics develops fever and eosinophilia (4.5 × 10⁹/L). He is otherwise well. Stool examination shows hookworm eggs (thin-shelled, oval, 60 × 40 µm). Which hookworm species cannot be distinguished by egg morphology alone?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EAncylostoma duodenale and Necator americanus — their eggs are morphologically identical; species identification requires larval culture (Harada-Mori or charcoal culture method)

Hookworm eggs (Ancylostoma duodenale and Necator americanus) are morphologically IDENTICAL on standard light microscopy — they cannot be distinguished by egg examination alone. Species identification requires: (1) larval culture (Harada-Mori filter paper technique or charcoal culture) to observe L3 larval morphology, or (2) molecular methods (PCR). This distinction matters clinically: A. duodenale is more pathogenic (higher blood loss per worm, can undergo oral transmission) while N. americanus is percutaneous only. Treatment is the same: Albendazole 400 mg single dose or Mebendazole 500 mg single dose.

Reference: WHO 2022 – Soil-transmitted helminths; UKHSA 2023