U=U Evidence — SCE Infectious Diseases MCQ

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EasyHIV MedicineU=U EvidenceSCE Infectious Diseases

A 30-year-old man with HIV (CD4 350, VL <50 on ART) asks about the concept of Undetectable = Untransmittable (U=U). What is the evidence?

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Correct answer: E — The PARTNER 1 and 2 trials demonstrated ZERO HIV transmissions from virally suppressed PLWH (VL <200) to HIV-negative sexual partners across >76,000 acts of condomless sex — U=U is an evidence-based public health message

The PARTNER 1 (2016) and PARTNER 2 (2019) studies, along with the HPTN 052 trial, collectively demonstrated ZERO phylogenetically linked HIV transmissions from virally suppressed individuals (VL <200 copies/mL) across >135,000 condomless sex acts in serodifferent couples (both heterosexual and MSM). U=U is endorsed by BHIVA, UNAIDS, WHO, and the Lancet Commission on HIV. It is a cornerstone of modern HIV prevention messaging and has been shown to reduce HIV-related stigma and improve mental health in PLWH.

Reference: PARTNER 1&2 Studies; HPTN 052; BHIVA 2025 – U=U