skip to main content

PCNSL Treatment in HIV — SCE Infectious Diseases MCQ

Instant feedback + full explanation. One question, done properly.

HardHIV MedicinePCNSL Treatment in HIVSCE Infectious Diseases

A person with controlled HIV has biopsy-confirmed EBV-positive primary CNS diffuse large B-cell lymphoma and adequate renal function. What is the treatment backbone?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — High-dose methotrexate-based chemotherapy with effective antiretroviral therapy

The best answer is “High-dose methotrexate-based chemotherapy with effective antiretroviral therapy”. Modern HIV-associated PCNSL is treated with curative high-dose methotrexate-based regimens; ART, interaction management and infection prophylaxis are integrated rather than used as substitutes. BHIVA guidance governs investigation and treatment of HIV-associated disease and supports standard specialist care when HIV is virologically controlled. HIV-associated primary CNS lymphoma is diagnosed with imaging, CSF and tissue where required and treated with curative high-dose methotrexate-based specialist regimens alongside effective ART.

Reference: BHIVA clinical guidelines: https://bhiva.org/clinical-guidelines/ EHA–ESMO guideline for HIV-associated lymphomas: https://www.esmo.org/guidelines/guidelines-by-topic/haematological-malignancies/hiv-associated-lymphomas