skip to main content

CGD Lifelong Prophylaxis — SCE Infectious Diseases MCQ

Instant feedback + full explanation. One question, done properly.

EasyImmunocompromised HostCGD Lifelong ProphylaxisSCE Infectious Diseases

A 45-year-old man with chronic granulomatous disease (CGD) develops hepatic abscess. CT-guided aspiration yields thick pus. Culture grows Staphylococcus aureus. In addition to drainage and antibiotics, what prophylactic measures should be in place for CGD patients?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Lifelong Co-trimoxazole (antibacterial) plus Itraconazole (antifungal) prophylaxis — CGD patients require lifelong antimicrobial prophylaxis to prevent recurrent catalase-positive infections

CGD patients require lifelong prophylaxis: Co-trimoxazole (reduces bacterial infections by ~50%) plus Itraconazole (reduces Aspergillus infections — the leading cause of death in CGD). IFN-gamma therapy may additionally reduce serious infections. Without prophylaxis, CGD patients experience recurrent life-threatening infections with catalase-positive organisms. Prophylaxis should start at diagnosis and continue indefinitely. Annual screening for Aspergillus colonisation and monitoring of organ function (hepatic, renal) is recommended.

Reference: UK PID guidelines 2023 – CGD; NICE 2024 – Primary immunodeficiency