COCP and ART Interaction — SCE Infectious Diseases MCQ

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EasyHIV MedicineCOCP and ART InteractionSCE Infectious Diseases

A 35-year-old woman with well-controlled HIV (CD4 580, VL <50) presents requesting contraception. She is on DTG/TAF/FTC. She wants an oral combined hormonal contraceptive pill (COCP). Are there significant interactions between COCP and her ART?

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Correct answer: A — No clinically significant interaction between DTG/TAF/FTC and combined oral contraceptives — COCP can be used safely

DTG, BIC, TAF, and FTC have no clinically significant interactions with combined hormonal contraceptives (COCP, patch, ring) or progesterone-only methods. This differs from enzyme-inducing ART (some PIs, Efavirenz, Nevirapine) which can reduce contraceptive efficacy. The Liverpool Drug Interactions database confirms green (no interaction) for DTG and all hormonal contraceptives. This is important for reproductive counselling — reliable contraception should be actively discussed with all women of childbearing potential on ART.

Reference: BHIVA 2025 – ART guidelines; FSRH 2024 – Drug interactions with hormonal contraception; Liverpool Drug Interactions