skip to main content

Latent TB ART Adjustment — SCE Infectious Diseases MCQ

Instant feedback + full explanation. One question, done properly.

ModerateTuberculosisLatent TB ART AdjustmentSCE Infectious Diseases

A 30-year-old Ethiopian-born man with HIV on DTG/TAF/FTC has latent TB (IGRA positive, normal CXR). He opts for 3HR (Isoniazid plus Rifampicin for 3 months). What ART adjustment is needed?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Increase DTG to 50 mg BD while on Rifampicin (Rifampicin reduces DTG by ~50%); return to 50 mg OD two weeks after Rifampicin stops

DTG must be doubled to 50 mg BD with Rifampicin. Alternative: Isoniazid monotherapy for 6 months requires no ART dose change.

Reference: NICE NG33 2016; BHIVA 2022; BNF 2024