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Itraconazole Absorption — SCE Infectious Diseases MCQ

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EasyFungal InfectionsItraconazole AbsorptionSCE Infectious Diseases

A 55-year-old man on Itraconazole for CPA has a subtherapeutic trough of 0.3 mg/L. He takes capsules on an empty stomach with water. How can absorption be improved?

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Correct answer: ATake capsules with a full meal and an acidic drink (cola, orange juice) — Itraconazole capsules require gastric acid and food for absorption

Itraconazole capsule absorption is pH and food-dependent. PPIs dramatically reduce levels. Solution formulation absorbs better in fasting.

Reference: BNF 2024 – Itraconazole; BSAC 2024