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Otogenic Brain Abscess — SCE Infectious Diseases MCQ

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ModerateCNS InfectionOtogenic Brain AbscessSCE Infectious Diseases

A 55-year-old man with chronic suppurative otitis media develops a temporal lobe brain abscess. CT brain shows a 3 cm ring-enhancing lesion in the right temporal lobe with surrounding oedema. He has headache, fever, and expressive dysphasia. What empirical antibiotic regimen covers the most likely organisms?

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Correct answer: EIV Ceftriaxone 2 g BD plus IV Metronidazole 500 mg TDS

Otogenic brain abscess (temporal lobe or cerebellum) is caused by direct extension or haematogenous spread from chronic middle ear/mastoid infection. The microbiology reflects the middle ear flora: mixed aerobic-anaerobic organisms including streptococci (particularly S. anginosus group), anaerobes (Bacteroides, Prevotella, Fusobacterium), and Gram-negatives (Proteus, Pseudomonas). Empirical treatment is IV Ceftriaxone (covering streptococci and Gram-negatives) plus IV Metronidazole (anaerobes). Neurosurgical assessment for aspiration or excision is essential. Total duration is typically 6–8 weeks.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/infections