A man with myeloma is starting bortezomib, lenalidomide and dexamethasone. He had childhood chickenpox and is VZV-IgG positive. Which preventive

Question

A man with myeloma is starting bortezomib, lenalidomide and dexamethasone. He had childhood chickenpox and is VZV-IgG positive. Which preventive strategy is required specifically because the regimen contains bortezomib?

Accepted Answer

Oral aciclovir or valaciclovir prophylaxis during treatment

Answer

Recombinant zoster vaccine as the only preventive measure

Answer

Varicella-zoster immunoglobulin before each treatment cycle

Answer

VZV-IgG monitoring before each bortezomib treatment cycle

Answer

Pre-emptive antiviral therapy only after VZV PCR positivity

VZV Prophylaxis in Myeloma — SCE Infectious Diseases MCQ

A man with myeloma is starting bortezomib, lenalidomide and dexamethasone. He had childhood chickenpox and is VZV-IgG positive. Which preventive strategy is required specifically because the regimen contains bortezomib?