Acetazolamide and ART — SCE Infectious Diseases MCQ

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EasyTravel Medicine & VaccinationAcetazolamide and ARTSCE Infectious Diseases

A 30-year-old woman with HIV (CD4 600, VL <50 on ART) plans a trip to altitude (4,500 m) in Peru. She requests Acetazolamide for altitude sickness prophylaxis. She is on DTG/TAF/FTC. Is there a drug interaction?

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Correct answer: C — No significant interaction — Acetazolamide can be used safely with DTG/TAF/FTC

Acetazolamide (a carbonic anhydrase inhibitor) has no significant interaction with Dolutegravir, TAF, or FTC. It can be safely prescribed for altitude sickness prophylaxis (125–250 mg BD starting 1–2 days before ascent). The Liverpool Drug Interactions database confirms no clinically relevant interaction. General travel advice for PLWH should include ensuring adequate ART supply, awareness of time zone changes for dosing, and malaria/vaccination considerations.

Reference: Liverpool Drug Interactions 2024; BHIVA 2024 – Travel in HIV; NaTHNaC 2024