Urethral Chlamydia — SCE Infectious Diseases MCQ

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EasySTIsUrethral ChlamydiaSCE Infectious Diseases

A 28-year-old man presents with urethral discharge. NAAT is positive for Chlamydia trachomatis. He has no drug allergies. What is the first-line treatment per BASHH 2018 guidelines?

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Correct answer: E — Doxycycline 100 mg BD for 7 days

BASHH 2018 guidelines changed the first-line treatment for uncomplicated genital chlamydia from Azithromycin 1 g single dose to Doxycycline 100 mg BD for 7 days. This was based on evidence of superior microbiological cure rates with Doxycycline, particularly for rectal chlamydial infection (where Azithromycin has significantly lower efficacy). Azithromycin 1 g remains an alternative when adherence to 7 days is a concern. Partner notification within the last 4 weeks (or last sexual partner) is essential.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/infections