Malaria Prophylaxis in HIV — SCE Infectious Diseases MCQ

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EasyTravel Medicine & VaccinationMalaria Prophylaxis in HIVSCE Infectious Diseases

A 38-year-old man with HIV (CD4 580, VL <50 on DTG/TAF/FTC) is planning a holiday to a country where Vivax malaria is prevalent. He is prescribed Chloroquine prophylaxis. What additional consideration applies?

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Correct answer: D — No significant interaction between Chloroquine and DTG/TAF/FTC — Chloroquine prophylaxis is appropriate

Chloroquine has no significant drug interactions with DTG, TAF, or FTC and can be safely used for malaria prophylaxis in P. vivax-only areas. For P. falciparum areas requiring Atovaquone/Proguanil or Mefloquine, interactions should be checked but are generally manageable. Doxycycline is also safe with INSTI-based ART. The Liverpool Drug Interactions database should be checked for any specific ART/antimalarial combination. Key interactions occur with Mefloquine and some PI-based regimens.

Reference: BHIVA 2024 – Vaccination/travel in HIV; Liverpool Drug Interactions 2024; UKHSA 2024 – Malaria prevention