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Idiopathic CD4 Lymphocytopenia — SCE Infectious Diseases MCQ

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HardImmunocompromised HostIdiopathic CD4 LymphocytopeniaSCE Infectious Diseases

Cerebral toxoplasmosis occurs in an HIV-negative adult without medicines or malignancy causing immunosuppression. Which finding supports idiopathic CD4 lymphocytopenia?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — CD4 below 300 cells/µL twice without HIV or another cause

Explanation lettering: B = shown as A · D = shown as B · A = shown as C · E = shown as D · C = shown as E

A is correct: persistent unexplained CD4 lymphocytopenia on repeated testing is required. B is neither sufficiently low nor repeated; C–E define different immune defects.

Reference: BHIVA clinical guidelines: https://bhiva.org/Clinical-Guidelines/