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Herpes Zoster Treatment — SCE Infectious Diseases MCQ

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EasyInfection Prevention & ControlHerpes Zoster TreatmentSCE Infectious Diseases

A 35-year-old man develops Herpes zoster affecting the T10 dermatome. He is immunocompetent and otherwise well. He presents within 48 hours of rash onset. What is the recommended antiviral treatment?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Oral Aciclovir 800 mg five times daily for 7 days (or Valaciclovir 1 g TDS for 7 days)

NICE CKS recommends oral antiviral treatment for immunocompetent patients with herpes zoster if presenting within 72 hours of rash onset AND aged ≥50, or if the rash is severe, affects the ophthalmic division (V1), or the patient is at higher risk of complications. In practice, many clinicians treat all adults presenting within 72 hours. Oral Aciclovir 800 mg five times daily for 7 days or Valaciclovir 1 g TDS for 7 days are the standard regimens. IV therapy is reserved for disseminated or complicated zoster.

Reference: NICE CKS 2024 – Shingles; BNF 2024 – Aciclovir