A 45-year-old man with cirrhosis (Child-Pugh C) is listed for liver transplant. His hepatitis B serology shows: HBsAg positive, HBeAg negative,

Question

A 45-year-old man with cirrhosis (Child-Pugh C) is listed for liver transplant. His hepatitis B serology shows: HBsAg positive, HBeAg negative, anti-HBe positive, HBV DNA

Accepted Answer

Lifelong HBIG plus nucleos(t)ide analogue (or nucleos(t)ide analogue alone in some protocols) to prevent HBV recurrence in the graft

Answer

HBV vaccination of the donor is sufficient as the preferred next diagnostic investigation in this patient

Answer

Switch Entecavir to Interferon post-transplant as the preferred next diagnostic investigation in this patient

Answer

HBIG for 1 year then stop as the preferred next diagnostic investigation at this stage in the clinical context described

Answer

No prophylaxis needed as the preferred next diagnostic investigation at this stage in the clinical context described

HBV Post-Transplant Prophylaxis — SCE Infectious Diseases MCQ

A 45-year-old man with cirrhosis (Child-Pugh C) is listed for liver transplant. His hepatitis B serology shows: HBsAg positive, HBeAg negative, anti-HBe positive, HBV DNA <20 IU/mL on Entecavir. He undergoes transplantation successfully. What HBV prophylaxis is needed post-transplant?